droplet microfluidic chip  (Autodesk Inc)

Journal: ACS Omega

Article Title: 3D-Printed Microfiltration Membranes via Dual-Wavelength Microstereolithography

doi: 10.1021/acsomega.5c05746

Figure Lengend Snippet: (a) Schematic illustration of the microfluidic emulsion fabrication setup to prepare monodisperse emulsions using a commercial microfluidic chip (focused-flow droplet generator), along with the microscopy image of the fabricated emulsion (scale bar is 50 μm)). (b) Optical microscopy image of the chip used for emulsion fabrication.

Article Snippet: Monodisperse O/W emulsion is fabricated using a focused-flow droplet generator microfluidic chip (Micronit Microfluidics B.V., The Netherlands).

Techniques: Emulsion, Microscopy

Journal: Small (Weinheim an Der Bergstrasse, Germany)

Article Title: Dynamic Liposome Sensing Platform to Wirelessly Ensure Nucleic Acid Encapsulation via Non‐Contact Perception

doi: 10.1002/smll.202409949

Figure Lengend Snippet: Ampullae of Lorenzini, a specialized organ in elasmobranch fishes, inspired the development of a dynamic liposome sensing (DLs) platform. a) Schematic image of shark's ampullae of Lorenzini which consists of surface pores connected to sensory neuron cells to sense weak potential variation, generated by biological activity. b) Concept illustrations of an electroreceptor inspired by elasmobranch fishes, by integrating the R2R printed e SWCNT‐TFT array into a droplet microfluidic system, including a cross‐sectional view of e SWCNT‐TFT based electroreceptor. c) Schematic energy band diagrams showing an aqueous droplet acting as top‐gate potential on e SWCNT‐TFT, along with graphs depicting the current response and V th variations for the aqueous droplet. d) Perspective product image based on a wireless monitoring platform of DLs.

Article Snippet: The droplet microfluidic chips were designed using CAD software (SolidWorks, Dassault system).

Techniques: Generated, Activity Assay

Journal: Small (Weinheim an Der Bergstrasse, Germany)

Article Title: Dynamic Liposome Sensing Platform to Wirelessly Ensure Nucleic Acid Encapsulation via Non‐Contact Perception

doi: 10.1002/smll.202409949

Figure Lengend Snippet: A dual‐gate concept of an electroreceptor and a droplet microfluidic chip will be used to construct the DLs platform. a) Circuit schematic of dual‐gate TFT for e SWCNT‐TFT. b) Transfer characteristics of dual‐gate SWCNT‐TFT with various top‐gate potentials from −10 V to +10 V at a step of 2 V. c) Energy band diagram of the dual‐gate TFT like e SWCNT‐TFT showing the conduction band ( E c ), intrinsic Fermi level ( E i ), Fermi level ( E F ), and valence band ( E v ) under different net charges of aqueous droplets which act as applied positive top‐gate voltages. d) 3D structure image of UV curable polymer‐based droplet microfluidic chip (two inlets and one outlet, channel height ≈170 µm, channel width ≈500 µm) and their water droplet formation images depending on the flow rate of oil and water. e) Ambient stability of e SWCNT‐TFT under continuous water droplet flow in a droplet microfluidic channel of the DLs platform.

Article Snippet: The droplet microfluidic chips were designed using CAD software (SolidWorks, Dassault system).

Techniques: Construct, Polymer

Journal: Small (Weinheim an Der Bergstrasse, Germany)

Article Title: Dynamic Liposome Sensing Platform to Wirelessly Ensure Nucleic Acid Encapsulation via Non‐Contact Perception

doi: 10.1002/smll.202409949

Figure Lengend Snippet: Sensing performance of the e SWCNT‐TFT‐based sensing unit. a) Transfer characteristics to the PBS droplets on different thicknesses of CYTOP‐coated SWCNT‐TFT in the droplet microfluidic chip. b) Threshold voltage (V th ) variation on different thicknesses of CYTOP‐coated SWCNT‐TFT for the PBS droplets. c) Attained transfer characteristics while continuously passing oil and PBS droplets on the CYTOP‐coated SWCNT‐TFT with the speed of 1 µL min −1 . An inset graph represents the shaded column of the transfer curve to show the sensor's response as PBS droplets pass through the oil to demonstrate consistent detection performance. The current maximum corresponds to the PBS droplet while the minimum represents the signal of the oil phase. d) Representative fluorescence images of stained liposomes using DiI (red), DNA stained with DAPI (blue), and DNA‐liposome complexes (magenta). e) Transfer characteristics to the series of oil and droplets with PBS, DNA with PBS, liposomes with PBS, and DNA‐loaded liposomes in PBS on the droplet microfluidic chip. f) V th variations for the oil and droplets with PBS, DNA, liposomes, and DNA‐loaded liposomes in PBS.

Article Snippet: The droplet microfluidic chips were designed using CAD software (SolidWorks, Dassault system).

Techniques: Fluorescence, Staining, Liposomes

Journal: ACS biomaterials science & engineering

Article Title: Microfluidic Systems For Manufacturing of Microparticle-Based Drug-Delivery Systems: Design, Construction, and Operation

doi: 10.1021/acsbiomaterials.2c00066

Figure Lengend Snippet: Commercially Available Droplet Generators and Their Specifications

Article Snippet: Additionally, this droplet generator had a flow-focusing nozzle configuration with a 100 μ m wide and 105 μ m long elliptical geometry that could produce PLGA microparticles with a target particle size of 9–20 μ m. Table 3. material configuration droplet diameter emulsion type surface coating provider PDMS T-junction flow focusing 15–1500 μ m O/W hydrophilic Dropletex a W/O hydrophobic Dropletex flow focusing 30–100 μ m W/O none Elveflow T-junction flow focusing 30–300 μ m W/O none Darwin Microfluidics glass T-junction flow focusing 2–150 μ m O/W hydrophilic Dolomite W/O W/O/W b hydrophobic fluorophilic Dolomite flow focusing 9–140 μ m O/W hydrophilic Micronit a W/O W/O/W hydrophobic Micronit flow focusing 40–250 μ m O/W hydrophilic Darwin Microfluidics PC T-junction flow focusing 10–100 μ m O/W W/O none microfluidic ChipShop a COC T-junction flow focusing 10–100 μ m O/W none microfluidic ChipShop W/O microfluidic ChipShop flow focusing 20–100 μ m O/W W/O none On-Chip Technologies PMMA Y-junction flow focusing 30–80 μ m O/W hydrophilic Cellix W/O hydrophobic Cellix resin coflow focusing 40–130 μ m O/W W/O none Fluigent Open in a separate window a Provider offers custom-designed device production for a given device configuration. b Two droplet generators are connected in series.

Techniques: Emulsion